Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.

doi:10.1016/j.nbd.2011.06.017

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Article

Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.

Neurobiology of disease - 1 Nov 2011

Nuber Silke, Petrasch-Parwez Elisabeth, Arias-Carrión Oscar, Koch Leanie, Kohl Zacharias, Schneider Jacqueline, Calaminus Carsten, Dermietzel Rolf, Samarina Anna, Boy Jana, Nguyen Huu P, Teismann Peter, Velavan Thirumalaisamy Palanichamy, Kahle Philipp J, von Hörsten Stephan, Fendt Markus, Krüger Rejko, Riess Olaf

Abstract excerpt

Mutations in the N-terminus of the gene encoding α-synuclein (α-syn) are linked to autosomal dominantly inherited Parkinson's disease (PD). The vast majority of PD patients develop neuropsychiatric symptoms preceding motor impairments. During this premotor stage, synucleinopathy is first detectable in the olfactory bulb (OB) and brain stem nuclei; however its impact on interconnected brain regions and related...

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PMID: 21767644
DOI: 10.1016/j.nbd.2011.06.017

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