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Article

Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice

31 Jan 2017

Abstract excerpt

BACKGROUND: Synucleinopathies such as Parkinson's disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucial for synaptic functions in the healthy brain. Transgenic animal models of synucleinopathies are frequently based on over-expression of human wild type or mutated α-synuclein under the regulatory...

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PMID: 28143405
DOI: 10.1186/s12868-017-0341-8

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