Article

Defining the relevant combinatorial space of the PKC/CARD-CC signal transduction nodes

2017-12-04

Abstract excerpt

Biological signal transduction typically display a so-called bow-tie or hour glass topology: Multiple receptors lead to multiple cellular responses but the signals all pass through a narrow waist of central signaling nodes. One such critical signaling node for several inflammatory and oncogenic signaling pathways in humans are the CARD-CC / Bcl10 / MALT1 (CBM) complexes, which get activated by upstream protein kin...

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Literature Corpus work: 8c487e3f-1707-562d-8c74-3860b63fc0ec
DOI: 10.1101/228767

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