Article

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration

2023-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated actin cytoskeleton gives rise to aberrant cell motility and metastatic spread of tumor cells. This study evaluates the effect of overexpression of wild-type vs functional mutants of MRTF-A on migration and invasion of breast cancer (BC) cells. Our studies indicate that SRF’s interaction is critical for MRTF-A-induced promotion of both 2D and 3D cell migration, while the SAP-domain f...

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Identifiers and source

Literature Corpus work: 90b16c7f-d9d0-555b-92df-8997efa62cb9
DOI: 10.1101/2023.12.21.572883

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