Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design.

Abstract excerpt

Rationally designing drugs that last longer in the face of biological evolution is a critical objective of drug discovery. However, this goal is thwarted by the diversity and stochasticity of evolutionary trajectories that drive uncertainty in the clinic. Although biophysical models can qualitatively predict whether a mutation causes resistance, they cannot quantitatively predict the relative abundance of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug Design
• Share to Drug Development
• Share to Drug Resistance, Neoplasm