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Article

Genetic, biochemical, and clinical features of chronic granulomatous disease.

Medicine - 1 May 2000

Segal B H, Leto T L, Gallin J I, Malech H L, Holland S M

Abstract excerpt

The reduced nicotinamide dinucleotide phosphate (NADPH) oxidase complex allows phagocytes to rapidly convert O2 to superoxide anion which then generates other antimicrobial reactive oxygen intermediates, such as H2O2, hydroxyl anion, and peroxynitrite anion. Chronic granulomatous disease (CGD) results from a defect in any of the 4 subunits of the NADPH oxidase and is characterized by recurrent life-threatening...

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Identifiers

PMID: 10844936
DOI: 10.1097/00005792-200005000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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