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Haploinsufficiency of the brain-derived neurotrophic factor gene is associated with reduced pain sensitivity

27 Feb 2019

Abstract excerpt

Rare pain-insensitive individuals offer unique insights into how pain circuits function and have led to the development of new strategies for pain control. We investigated pain sensitivity in humans with WAGR (Wilms tumor, aniridia, genitourinary anomaly, and range of intellectual disabilities) syndrome, who have variably sized heterozygous deletion of the 11p13 region. The deletion region can be inclusive or...

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PMID: 30855519
DOI: 10.1097/j.pain.0000000000001485

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