Article
Pain genes.
PLoS genetics - 25 Jul 2008
Foulkes Tom, Wood John N
Abstract excerpt
Pain, which afflicts up to 20% of the population at any time, provides both a massive therapeutic challenge and a route to understanding mechanisms in the nervous system. Specialised sensory neurons (nociceptors) signal the existence of tissue damage to the central nervous system (CNS), where pain is represented in a complex matrix involving many CNS structures. Genetic approaches to investigating pain pathways...
Topics
- Afferent Pathways
- Animals
- Forecasting
- Gene Deletion
- Genes
- Humans
- Mice
- Mice, Transgenic
- Models, Neurological
- Nociceptors
- Pain
- Peripheral Nervous System
- Physical Chromosome Mapping
- Polymorphism, Single Nucleotide
- Twin Studies as Topic