Article

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

2022-09-05

Abstract excerpt

We performed the first integrative single-cell and spatial transcriptomic analysis on HPV-negative oral squamous cell carcinoma (OSCC) to comprehensively characterize tumor core (TC) and leading edge (LE) transcriptional architectures. We show that the TC and LE are characterized by unique transcriptional profiles, cellular compositions, and ligand-receptor interactions. We demonstrate that LE regions are conserve...

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Literature Corpus work: ab8b2dec-7ea3-5a88-b5a4-20d672dcb625
DOI: 10.1101/2022.09.04.505581

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