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Artificial Intelligence–driven spatial transcriptomics in OSCC: Mapping the tumor microenvironment and personalizing therapy

1 Nov 2025

Abstract excerpt

Spatial transcriptomics (ST) represents a transformative approach in cancer research, offering high-resolution insights into the spatial organization of gene expression within tissues, particularly relevant for the complex tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC). Unlike conventional bulk RNA sequencing, which masks spatial heterogeneity, ST retains the architectural context of tumors,...

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PMID: 41282271
DOI: 10.1016/j.jobcr.2025.10.015

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