Article

Revealing Molecular Mechanisms of Early-Onset Tongue Cancer by Spatial Transcriptomics

2023-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Tongue cancer at a young age demonstrates an increase in incidence, aggressiveness, and poor response to therapy. Classic etiological factors for head and neck tumors such as tobacco, alcohol, and human papillomavirus are not related to early-onset tongue cancer. Mechanisms of development and progression of this cancer remain unclear. In this study, we performed spatial whole-transcriptome profi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e16b274-7d29-533d-b6f1-f5e4aed0f44c
DOI: 10.1101/2023.10.12.562054

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Revealing Molecular Mechanisms of Early-Onset Tongue Cancer by Spatial TranscriptomicsDOI 10.1101/2023.10.12.562054Read

Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomicsSemantic proximity Read

Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinomaSemantic proximity Read

The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma.Semantic proximity Read

Integrative analysis of spatiotemporal transcriptomics delineates dynamic cell states in squamous tumorigenesisSemantic proximity Read

Identification of key biomarkers associated with oral squamous cell carcinoma prognosis and immune responseSemantic proximity Read

Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrenceSemantic proximity Read

Transcriptomic analysis predicts the risk of progression of premalignant lesions in human tongueSemantic proximity Read

Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancerSemantic proximity Read

Transcriptional reprogramming in oral squamous carcinomaSemantic proximity Read

Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancerSemantic proximity Read

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy responseSemantic proximity Read

Identiﬁcation of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics AnalysisSemantic proximity Read