Article
Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers.
eLife - 20 Jun 2023
Defour Jean-Philippe, Leroy Emilie, Dass Sharmila, Balligand Thomas, Levy Gabriel, Brett Ian C, Papadopoulos Nicolas, Mouton Céline, Genet Lidvine, Pecquet Christian, Staerk Judith, Smith Steven O, Constantinescu Stefan N
Abstract excerpt
Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor dimer can lead to different signaling outputs. Here we addressed the structural basis of activation for receptor mutations S505N and W515K that induce...
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