Article

Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: Measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy

2026-03-30

Abstract excerpt

<title>Abstract</title> <p> Background The aggregate presence of cell free CTCF-DNA (cfCTCF-DNA) nucleoproteins in plasma has been reported. But the occupancy of individual CTCF binding sites in plasma cfCTCF-DNA has not been studied. Results For the first time, we have isolated endogenous plasma cfCTCF-DNA by chromatin immunoprecipitation (ChIP) and sequenced the associated cfDNA (ChIP-Seq) in samples from ca...

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Literature Corpus work: ab37c9af-2617-5bb5-8776-9f423c32ee9c
DOI: 10.21203/rs.3.rs-8047483/v2

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