Article

Simulating cell-free chromatin using preclinical models for cancer-specific biomarker discovery

2023-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Cell-free chromatin (cf-chromatin) is a rich source of biomarkers across various conditions, including cancer. Tumor-derived circulating cf-chromatin can be profiled for epigenetic features, including nucleosome positioning and histone modifications that govern cell type-specific chromatin conformations. However, the low fractional abundance of tumor-derived cf-chromatin in blood and constrained...

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Literature Corpus work: 04b80609-d581-52e0-8811-71a1ba970212
DOI: 10.1101/2023.11.16.567416

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