Article

Generative machine learning of ADAR substrates for precise and efficient RNA editing

2024-09-28

Abstract excerpt

Adenosine Deaminase Acting on RNA (ADAR) converts adenosine to inosine within certain double-stranded RNA structures. However, ADAR’s promiscuous editing and poorly understood specificity hinder therapeutic applications. We present an integrated approach combining high-throughput screening (HTS) with generative deep learning to rapidly engineer efficient and specific guide RNAs (gRNAs) to direct ADAR’s activity to...

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Literature Corpus work: c8de60a6-41f1-51c5-837a-d544f2578e75
DOI: 10.1101/2024.09.27.613923

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