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Article

Towards parsimonious generative modeling of RNA families.

Nucleic acids research - 10 Jun 2024

Calvanese Francesco, Lambert Camille N, Nghe Philippe, Zamponi Francesco, Weigt Martin

Abstract excerpt

Generative probabilistic models emerge as a new paradigm in data-driven, evolution-informed design of biomolecular sequences. This paper introduces a novel approach, called Edge Activation Direct Coupling Analysis (eaDCA), tailored to the characteristics of RNA sequences, with a strong emphasis on simplicity, efficiency, and interpretability. eaDCA explicitly constructs sparse coevolutionary models for RNA...

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Identifiers

PMID: 38661206
DOI: 10.1093/nar/gkae289
PMCID: PMC11162787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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