Article

Helix: a structure-aware deep learning model for accurate prediction of A-to-I RNA editing by endogenous ADARs

2025-12-20

Abstract excerpt

Adenosine deaminase acting on RNA (ADAR) converts adenosine to inosine within double-stranded RNA (dsRNA) and can be co-opted for therapeutic RNA editing by introducing dsRNA substrates in trans using programmable guide RNAs (gRNAs). However, ADAR’s natural promiscuity necessitates sophisticated gRNA designs to achieve efficient and specific editing. Here we present Helix, a predictive model that achieves highly a...

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Literature Corpus work: eabd15cd-7539-5ae1-b51b-4a73f8e1401f
DOI: 10.64898/2025.12.18.695251

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