Article

A generative-AI framework for target-Specific MicroRNAs towards RNAi-based drug design

2026-05-11

Abstract excerpt

MicroRNA (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the target messenger RNA (mRNA), whose versatility has inspired RNA-interference (RNAi)-based drug designs. However, off-target effects lead to unintended gene silencing and toxicity. Existing methods suffer from experimental data scarcity and fail to effectively integrate target specificity into designing de novo small interfe...

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Literature Corpus work: 90954137-8bd6-5732-9cdb-a6c0dc0fcf82
DOI: 10.64898/2026.05.07.723585

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