Article

Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

2021-08-31

Abstract excerpt

Osteosarcoma is an aggressive malignancy characterized by high genomic complexity. Identification of few recurrent mutations in protein coding genes suggests that somatic copy-number aberrations (SCNAs) are the genetic drivers of disease. Models around genomic instability conflict - it is unclear if osteosarcomas result from pervasive ongoing clonal evolution with continuous optimization of the fitness landscape o...

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Literature Corpus work: aaf428c2-23bd-50e2-be84-8cd2ebb2b7d4
DOI: 10.1101/2021.08.30.458268

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