Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Informed Targeted Therapy for Osteosarcoma

28 Sept 2018

Abstract excerpt

Abstract Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially unchanged for more than 30 years. Osteosarcoma is characterized by widespread and recurrent somatic copy-number alterations (SCNA) and structural rearrangements. In contrast, few recurrent point mutations in protein-coding genes have been identified, suggesting that genes within SCNAs are key oncogenic drivers in this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Molecular Biology Techniques and Applications
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30266815
DOI: 10.1158/2159-8290.cd-17-1152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Informed Targeted Therapy for OsteosarcomaPMID 30266815Read ↗

Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicineSemantic proximity Read ↗

Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy.Semantic proximity Read ↗

Patient Derived Xenografts for Genome-Driven Therapy of OsteosarcomaSemantic proximity Read ↗

The Variable Genomic Landscape During Osteosarcoma Progression: Insights From a Longitudinal WGS Analysis.Semantic proximity Read ↗

The variable genomic landscape during osteosarcoma progression: insights from a longitudinal WGS analysisSemantic proximity Read ↗

Analysis of a large osteosarcoma sequencing data set elucidates patterns of genomic alterations.Semantic proximity Read ↗

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency.Semantic proximity Read ↗

Future directions in the treatment of osteosarcoma.Semantic proximity Read ↗

Advances in Target Therapy Research in OsteosarcomaSemantic proximity Read ↗

Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable AlterationsSemantic proximity Read ↗

Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate TherapiesSemantic proximity Read ↗

Genomic Profiling of Sarcomas: A Promising Weapon in the Therapeutic ArsenalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.