Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.

doi:10.1158/0008-5472.CAN-23-0385

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Article

Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.

Cancer research - 15 Nov 2023

Kinnaman Michael D, Zaccaria Simone, Makohon-Moore Alvin, Arnold Brian, Levine Max F, Gundem Gunes, Arango Ossa Juan E, Glodzik Dominik, Rodríguez-Sánchez M Irene, Bouvier Nancy, Li Shanita, Stockfisch Emily, Dunigan Marisa, Cobbs Cassidy, Bhanot Umesh K, You Daoqi, Mullen Katelyn, Melchor Jerry P, Ortiz Michael V, O'Donohue Tara J, Slotkin Emily K, Wexler Leonard H, Dela Cruz Filemon S, Hameed Meera R, Glade Bender Julia L, Tap William D, Meyers Paul A, Papaemmanuil Elli, Kung Andrew L, Iacobuzio-Donahue Christine A

Abstract excerpt

Multiple large-scale genomic profiling efforts have been undertaken in osteosarcoma to define the genomic drivers of tumorigenesis, therapeutic response, and disease recurrence. The spatial and temporal intratumor heterogeneity could also play a role in promoting tumor growth and treatment resistance. We conducted longitudinal whole-genome sequencing of 37 tumor samples from 8 patients with relapsed or refractory...

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Identifiers

PMID: 37812025
DOI: 10.1158/0008-5472.CAN-23-0385
PMCID: PMC10646480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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