Article

Human iPSC gene signatures and X chromosome dosage impact response to WNT inhibition and cardiac differentiation fate

2019-05-24

Abstract excerpt

Non-genetic variability in human induced pluripotent stem cell (iPSC) lines impacts their differentiation outcome, limiting their utility for genetic studies and clinical applications. Despite the importance of understanding how non-genetic molecular variability influences iPSC differentiation outcome, large-scale studies capable of addressing this question have not yet been conducted. Here, we performed 258 direc...

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Literature Corpus work: 890450e9-1d1e-523c-90d7-8c3a8ca03fe7
DOI: 10.1101/644633

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