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Article

The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

4 Jun 2019

Abstract excerpt

Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer’s disease (AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene expression is regulated in a region-specific manner over the course of normal aging and in neurodegenerative disease are only beginning to be deciphered. Herein, we used a specific marker of microglia (TMEM119) and a cell-type expression...

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PMID: 31214167
DOI: 10.3389/fimmu.2019.01170

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