Article

Long-read cDNA sequencing reveals novel isoforms and spliceosome-mutant-enriched transcripts in AML and MDS

2026-05-21

Abstract excerpt

The alternative splicing landscape of the leukemia transcriptome remains poorly characterized, since short-read sequencing cannot resolve complete transcript structures. Using the Oxford Nanopore cDNA platform, we generated nearly 2 billion long reads (median 25.8 million per sample) from 71 human samples, including 48 acute myeloid leukemia or myelodysplastic syndrome samples, 25 of which had splicing-factor gene...

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Literature Corpus work: 897219fd-a342-58ec-a0ba-f036107332a0
DOI: 10.64898/2026.05.20.726635

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