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Aberrant splicing and drug resistance in AML

10 Sept 2016

Abstract excerpt

The advent of next-generation sequencing technologies has unveiled a new window into the heterogeneity of acute myeloid leukemia (AML). In particular, recurrent mutations in spliceosome machinery and genome-wide aberrant splicing events have been recognized as a prominent component of this disease. This review will focus on how these factors influence drug resistance through altered splicing of tumor suppressor...

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PMID: 27613060
DOI: 10.1186/s13045-016-0315-9

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