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Article

Improving AML Classification Using Splicing Signatures.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2020

Bowman Teresa V

Abstract excerpt

Mutations in spliceosomal components are prevalent in myelodysplastic syndromes, but less so in acute myeloid leukemia (AML). However, aberrant splicing is prolific in AML, suggesting deregulated splicing could contribute broadly to tumorigenesis. Elevated stress responses correlate with splicing dysfunction across myeloid malignancies, representing potentially novel therapeutic targets.See related article by...

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Topics

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Share to Leukemia, Myeloid, Acute
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Share to Myelodysplastic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32317289
DOI: 10.1158/1078-0432.CCR-20-1021
PMCID: PMC7367749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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