Article

ATF4-Mediated Metabolic Stress Response as a Therapeutic Vulnerability in Chordoma

2025-03-03

Abstract excerpt

Chordoma, a rare primary bone malignancy, currently lacks effective targeted therapies. Despite surgical resection and adjuvant radiotherapy, prognosis remains poor. Recent preclinical studies have highlighted potential therapeutic targets, including the transcription factor TBXT. However, clinical outcomes associated with therapies targeting TBXT remain underexplored or have been modest, warranting further invest...

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Literature Corpus work: aac02ac8-95fc-596a-8e85-8f9e3ec9a0f7
DOI: 10.1101/2025.02.27.640253

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