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ATF4 drives the resistance of T-ALL against FGFR1 inhibitors through amino acid metabolic reprogramming

2023-01-04

Abstract excerpt

<h4>Background: </h4> Abnormalities of FGFR1 have been reported in multiple malignancies, which proposes FGFR1 as a potential target for precision treatment, whereas drug resistance remains a formidable obstacle simultaneously. Methods RNA-seq analysis, mouse tumor models, and flow cytometry were performed to identify that the FGFR1 was a potential target in T-ALL. RNA-seq, ATAC-seq, targeted metabolomics analysi...

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Literature Corpus work
42f65f76-5256-5c7c-9eba-a9fb2f748a99
DOI
10.21203/rs.3.rs-2415441/v1
Open publication

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ATF4 drives the resistance of T-ALL against FGFR1 inhibitors through amino acid metabolic reprogrammingDOI 10.21203/rs.3.rs-2415441/v1
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