Article

Immune infiltration is linked to increased transcriptional activity and distinct metabolic profiles in chordomas

2025-11-05

Abstract excerpt

Chordomas are ultra-rare cancers from the axial skeleton with limited treatment options. Chordomas can exhibit immunogenic features, and immune checkpoint blockade has demonstrated clinical activity in some patients, yet the determinants of these responses remain poorly understood. We aimed to elucidate the biological basis of immunogenicity in chordomas through spatial transcriptomic and metabolomic analyses. We...

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Identifiers and source

Literature Corpus work: 32001083-067b-567c-b5c1-c5924aaaeddd
DOI: 10.1101/2025.11.04.686078

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