Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Boulaftali Yacine, Owens A Phillip, Beale Ashley, Piatt Raymond, Casari Caterina, Lee Robert H, Conley Pamela B, Paul David S, Mackman Nigel, Bergmeier Wolfgang

Abstract excerpt

OBJECTIVE: Platelets are important for the development and progression of atherosclerotic lesions. However, relatively little is known about the contribution of platelet signaling to this pathological process. Our recent work identified 2 independent, yet synergistic, signaling pathways that lead to the activation of the small GTPase Rap1; one mediated by the guanine nucleotide exchange factor, CalDAG-GEFI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Diseases
Share to Chemotaxis, Leukocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Neutrophil Infiltration

Share to Plaque, Atherosclerotic

Share to Platelet Adhesiveness

Share to rap1 GTP-Binding Proteins

Share to Receptors, Purinergic P2Y12

Source

Open in PubMed Open full text

Identifiers

PMID: 26988592
DOI: 10.1161/ATVBAHA.115.306347
PMCID: PMC4850098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.PMID 26988592Read ↗

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.Semantic proximity Read ↗

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.Semantic proximity Read ↗

Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammationSemantic proximity Read ↗

Expression of the Lyst(beige) mutation is atheroprotective in chow-fed apolipoprotein E-deficient mice.Semantic proximity Read ↗

A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice.Semantic proximity Read ↗

Discoidin Domain Receptor 1 on Bone Marrow–Derived Cells Promotes Macrophage Accumulation During AtherogenesisSemantic proximity Read ↗

Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report.Semantic proximity Read ↗

Increased Cell and Matrix Accumulation During Atherogenesis in Mice With Vessel Wall–Specific Deletion of Discoidin Domain Receptor 1Semantic proximity Read ↗

Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice.Semantic proximity Read ↗

Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice.Semantic proximity Read ↗

P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development.Semantic proximity Read ↗

Platelets are Protective in Early Abdominal Aortic Aneurysm FormationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.