Article
Role of sGC-dependent NO signalling and myocardial infarction risk.
Journal of molecular medicine (Berlin, Germany) - 1 Apr 2015
Wobst Jana, Kessler Thorsten, Dang Tan An, Erdmann Jeanette, Schunkert Heribert
Abstract excerpt
The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and...
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