Article
Dysfunctional nitric oxide signalling increases risk of myocardial infarction.
Nature - 19 Dec 2013
Erdmann Jeanette, Stark Klaus, Esslinger Ulrike B, Rumpf Philipp Moritz, Koesling Doris, de Wit Cor, Kaiser Frank J, Braunholz Diana, Medack Anja, Fischer Marcus, Zimmermann Martina E, Tennstedt Stephanie, Graf Elisabeth, Eck Sebastian, Aherrahrou Zouhair, Nahrstaedt Janja, Willenborg Christina, Bruse Petra, Brænne Ingrid, Nöthen Markus M, Hofmann Per, Braund Peter S, Mergia Evanthia, Reinhard Wibke, Burgdorf Christof, Schreiber Stefan, Balmforth Anthony J, Hall Alistair S, Bertram Lars, Steinhagen-Thiessen Elisabeth, Li Shu-Chen, März Winfried, Reilly Muredach, Kathiresan Sekar, McPherson Ruth, Walter Ulrich, Ott Jurg, Samani Nilesh J, Strom Tim M, Meitinger Thomas, Hengstenberg Christian, Schunkert Heribert
Abstract excerpt
Myocardial infarction, a leading cause of death in the Western world, usually occurs when the fibrous cap overlying an atherosclerotic plaque in a coronary artery ruptures. The resulting exposure of blood to the atherosclerotic material then triggers thrombus formation, which occludes the artery. The importance of genetic predisposition to coronary artery disease and myocardial infarction is best documented by...
Topics
- Animals
- Chaperonin Containing TCP-1
- Cyclic GMP
- Disease Susceptibility
- Exome
- Female