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Article

Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants.

Basic research in cardiology - 1 Jul 2016

Wobst Jana, von Ameln Simon, Wolf Bernhard, Wierer Michael, Dang Tan An, Sager Hendrik B, Tennstedt Stephanie, Hengstenberg Christian, Koesling Doris, Friebe Andreas, Braun Siegmund L, Erdmann Jeanette, Schunkert Heribert, Kessler Thorsten

Abstract excerpt

Stimulators of the soluble guanylyl cyclase (sGC) are emerging therapeutic agents in cardiovascular diseases. Genetic alterations of the GUCY1A3 gene, which encodes the α1 subunit of the sGC, are associated with coronary artery disease. Studies investigating sGC stimulators in subjects with CAD and carrying risk-related variants in sGC are, however, lacking. Here, we functionally investigate the impact of coding...

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PMID: 27342234
DOI: 10.1007/s00395-016-0570-5

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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