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Article

Proatherosclerotic Effect of the α1-Subunit of Soluble Guanylyl Cyclase by Promoting Smooth Muscle Phenotypic Switching.

The American journal of pathology - 1 Aug 2016

Segura-Puimedon Maria, Mergia Evanthia, Al-Hasani Jaafar, Aherrahrou Redouane, Stoelting Stephanie, Kremer Felix, Freyer Jennifer, Koesling Doris, Erdmann Jeanette, Schunkert Heribert, de Wit Cor, Aherrahrou Zouhair

Abstract excerpt

Soluble guanylate cyclase (sGC), a key enzyme of the nitric oxide signaling pathway, is formed as a heterodimer by various isoforms of its α and β subunit. GUCY1A3, encoding the α1 subunit, was identified as a risk gene for coronary artery disease and myocardial infarction, but its specific contribution to atherosclerosis remains unclear. This study sought to decipher the role of Gucy1a3 in atherosclerosis in...

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Identifiers

PMID: 27315776
DOI: 10.1016/j.ajpath.2016.04.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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