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Article

Genomic analyses of high-grade neuroendocrine gynecological malignancies reveal a unique mutational landscape and therapeutic vulnerabilities.

Molecular oncology - 1 Dec 2021

Mahdi Haider, Joehlin-Price Amy, Elishaev Esther, Dowlati Afshin, Abbas Ata

Abstract excerpt

High-grade neuroendocrine carcinoma of gynecologic origin (NEC-GYN) is a highly aggressive cancer that often affects young women. The clinical management of NEC-GYN is typically extrapolated from its counterpart, small cell carcinoma of the lung (SCLC), but, unfortunately, available therapies have limited benefit. In our NEC-GYN cohort, median progression-free survival (PFS) and overall survival (OS) were 1 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34245124
DOI: 10.1002/1878-0261.13057
PMCID: PMC8637558

Genes

CCDC6
KMT2C
KNL1
NCOR2
RB1

Provenance

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