Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.

doi:10.1158/1078-0432.CCR-15-2946

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Article

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2016

Rekhtman Natasha, Pietanza Maria C, Hellmann Matthew D, Naidoo Jarushka, Arora Arshi, Won Helen, Halpenny Darragh F, Wang Hangjun, Tian Shaozhou K, Litvak Anya M, Paik Paul K, Drilon Alexander E, Socci Nicholas, Poirier John T, Shen Ronglai, Berger Michael F, Moreira Andre L, Travis William D, Rudin Charles M, Ladanyi Marc

Abstract excerpt

PURPOSE: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive neoplasm, whose biologic relationship to small cell lung carcinoma (SCLC) versus non-SCLC (NSCLC) remains unclear, contributing to uncertainty regarding optimal clinical management. To clarify these relationships, we analyzed genomic alterations in LCNEC compared with other major lung carcinoma types. EXPERIMENTAL DESIGN: LCNEC...

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Identifiers

PMID: 26960398
DOI: 10.1158/1078-0432.CCR-15-2946
PMCID: PMC4995776

Genes

IMPACT
KEAP1
KRAS
STK11
MEN1
MYCL

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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