Article

Fumarate activates the IL-6/JAK/STAT3 pathway by inhibiting KDM4C-mediated H3K36me3 demethylation in FH-knockdown renal cancer cells

2024-08-17

Abstract excerpt

<title>Abstract</title> <p>Fumarate is a small molecule metabolite that plays a key role in the malignant transformation of cells, yet the underlying mechanism remains unclear. Herein, we discovered that accumulated fumarate in fumarate hydratase (FH)-knockdown ACHN and HK-2 cells competitively binds to α-ketoglutaric acid (α-KG), effectively inhibiting the activity of the histone demethylase KDM4C and significan...

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Literature Corpus work: aa788cfc-9607-55b3-a254-ca4b9f27a4ec
DOI: 10.21203/rs.3.rs-4739068/v1

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