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Article

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Genes & development - 15 Jun 2012

Xiao Mengtao, Yang Hui, Xu Wei, Ma Shenghong, Lin Huaipeng, Zhu Honguang, Liu Lixia, Liu Ying, Yang Chen, Xu Yanhui, Zhao Shimin, Ye Dan, Xiong Yue, Guan Kun-Liang

Abstract excerpt

Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate and succinate, respectively. Here we demonstrate that fumarate and succinate are competitive inhibitors of multiple α-k...

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Identifiers

PMID: 22677546
DOI: 10.1101/gad.191056.112
PMCID: PMC3387660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22677546-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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