Integrated Molecular Characterization of Fumarate Hydratase-deficient Renal Cell Carcinoma.

doi:10.1158/1078-0432.CCR-20-3788

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Article

Integrated Molecular Characterization of Fumarate Hydratase-deficient Renal Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2021

Sun Guangxi, Zhang Xingming, Liang Jiayu, Pan Xiuyi, Zhu Sha, Liu Zhenhua, Armstrong Cameron M, Chen Jianhui, Lin Wei, Liao Banghua, Lin Tianhai, Huang Rui, Zhang Mengni, Zheng Linmao, Yin Xiaoxue, Nie Ling, Shen Pengfei, Zhao Jinge, Zhang Haoran, Dai Jindong, Shen Yali, Li Zhiping, Liu Jiyan, Chen Junru, Liu Jiandong, Wang Zhipeng, Zhu Xudong, Ni Yuchao, Qin Dan, Yang Ling, Chen Yuntian, Wei Qiang, Li Xiang, Zhou Qiao, Huang Haojie, Yao Jin, Chen Ni, Zeng Hao

Abstract excerpt

PURPOSE: Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare but lethal subtype of RCC. Little is known about the genomic profile of FH-deficient RCC, and the therapeutic options for advanced disease are limited. To this end, we performed a comprehensive genomics study to characterize the genomic and epigenomic features of FH-deficient RCC. EXPERIMENTAL DESIGN: Integrated genomic,...

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PMID: 33414138
DOI: 10.1158/1078-0432.CCR-20-3788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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