Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.

doi:10.1158/1078-0432.CCR-18-1727

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Article

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2018

Shelar Sandeep, Shim Eun-Hee, Brinkley Garrett J, Kundu Anirban, Carobbio Francesca, Poston Tyler, Tan Jubilee, Parekh Vishwas, Benson Daniel, Crossman David K, Buckhaults Phillip J, Rakheja Dinesh, Kirkman Richard, Sato Yusuke, Ogawa Seishi, Dutta Shilpa, Velu Sadanandan E, Emberley Ethan, Pan Alison, Chen Jason, Huang Tony, Absher Devin, Becker Anja, Kunick Conrad, Sudarshan Sunil

Abstract excerpt

PURPOSE: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the contribution of L-2-HG to renal carcinogenesis and insight into the biochemistry and targets of this small molecule remains to be elucidated. EXPERIMENTAL DESIGN: Genetic and pharmacologic approaches to modulate L-2-HG levels were assessed for...

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PMID: 30108105
DOI: 10.1158/1078-0432.CCR-18-1727
PMCID: PMC6295227

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MDH2

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