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Article

Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers

2023-12-11

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in neurofibrillary degeneration and dementia. Immunotherapy targeting and resolving the pathological tau aggregates is known to improve cognitive deficits in AD animal models. The repeat domain of tau (TauRD) plays a pivotal role in tau-microtubule int...

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Literature Corpus work
aa70c54c-d8d5-5b84-942f-03216cdaf926
DOI
10.21203/rs.3.rs-3686019/v1
Open publication

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Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformersDOI 10.21203/rs.3.rs-3686019/v1
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