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Article

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.

Journal of neuroinflammation - 3 Sept 2014

Selenica Maj-Linda B, Davtyan Hayk, Housley Steven B, Blair Laura J, Gillies Anne, Nordhues Bryce A, Zhang Bo, Liu Joseph, Gestwicki Jason E, Lee Daniel C, Gordon Marcia N, Morgan Dave, Dickey Chad A

Abstract excerpt

BACKGROUND: Abnormal tau hyperphosphorylation and its accumulation into intra-neuronal neurofibrillary tangles are linked to neurodegeneration in Alzheimer's disease and similar tauopathies. One strategy to reduce accumulation is through immunization, but the most immunogenic tau epitopes have so far remained unknown. To fill this gap, we immunized mice with recombinant tau to build a map of the most immunogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25183004
DOI: 10.1186/s12974-014-0152-0
PMCID: PMC4167523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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