Article
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.
Alzheimer's research & therapy - 19 Jun 2018
Ji Mei, Xie Xi-Xiu, Liu Dong-Qun, Yu Xiao-Lin, Zhang Yue, Zhang Ling-Xiao, Wang Shao-Wei, Huang Ya-Ru, Liu Rui-Tian
Abstract excerpt
BACKGROUND: Truncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer's disease (AD) and frontotemporal dementia (FTD). Tau294-305, an epitope in the truncated tau, is essential for pathological tau-tau interaction and aggregation. A tau294-305-targeted approach may have beneficial effects in the treatment of AD and FTD. METHODS: In this study, we genetically fused tau294-305...
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