Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.

doi:10.1523/JNEUROSCI.4672-12.2013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Mar 2013

Davtyan Hayk, Ghochikyan Anahit, Petrushina Irina, Hovakimyan Armine, Davtyan Arpine, Poghosyan Anna, Marleau Annette M, Movsesyan Nina, Kiyatkin Anatoly, Rasool Suhail, Larsen Anna Kirstine, Madsen Peter Juul, Wegener Karen Malene, Ditlevsen Dorte Kornerup, Cribbs David H, Pedersen Lars Ostergaard, Agadjanyan Michael G

Abstract excerpt

The Alzheimer's disease (AD) process is understood to involve the accumulation of amyloid plaques and tau tangles in the brain. However, attempts at targeting the main culprits, neurotoxic Aβ peptides, have thus far proven unsuccessful for improving cognitive function. Recent clinical trials with passively administrated anti-Aβ antibodies failed to slow cognitive decline in mild to moderate AD patients, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Anti-Idiotypic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Immunologic

Share to Epitopes, B-Lymphocyte

Share to Guinea Pigs

Share to Macaca fascicularis

Share to Plaque, Amyloid

Share to Surface Plasmon Resonance

Share to Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 23486963
DOI: 10.1523/JNEUROSCI.4672-12.2013
PMCID: PMC3634356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.PMID 23486963Read ↗

mRNA vaccine platform demonstrates potent immunotherapeutic targeting of amyloid-β and tau pathologies in Alzheimer's diseaseSemantic proximity Read ↗

Vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer's disease.Semantic proximity Read ↗

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.Semantic proximity Read ↗

MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.Semantic proximity Read ↗

Targeting of phosphorylated tau at threonine 181 by a Qβ virus‐like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaquesSemantic proximity Read ↗

Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformersSemantic proximity Read ↗

Efficacy of a therapeutic vaccine using mutated β-amyloid sensitized dendritic cells in Alzheimer's mice.Semantic proximity Read ↗

Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.Semantic proximity Read ↗

Papillomavirus-Like Particles Are an Effective Platform for Amyloid-β Immunization in Rabbits and Transgenic MiceSemantic proximity Read ↗

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.Semantic proximity Read ↗

A preclinical and phase I clinical study of ex vivo-expanded amyloid beta-specific human regulatory T cells in Alzheimer’s diseaseSemantic proximity Read ↗

Epitope‐based DNA vaccine for Alzheimer's disease: Translational study in macaquesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.