Article

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

2024-02-26

Abstract excerpt

<title>Abstract</title> <p>Tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. We have developed over fifty anti-tau single domain antibodies (sdAbs) derived from phage display libraries of a llama immunized with recombinant and pathological tau immunogens. We examined the therapeutic potential of four of these sdAbs in <italic>Drosophila</italic> tauopathy model...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7456b157-a160-56b1-9039-1d84031855a3
DOI: 10.21203/rs.3.rs-3909421/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defectsDOI 10.21203/rs.3.rs-3909421/v1Read

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defectsSemantic proximity Read

Development of a pan‐tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregatesSemantic proximity Read

Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice StudiesSemantic proximity Read

Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery.Semantic proximity Read

Inhibition of tau neuronal internalization using anti-tau single domain antibodiesSemantic proximity Read

The <i>Drosophila</i> wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discoverySemantic proximity Read

Nanobodies targeting hnRNPA2/B1 and tauSemantic proximity Read

Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models.Semantic proximity Read

Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicitySemantic proximity Read

A toolbox of nanobodies developed and validated for diverse neuroscience research applicationsSemantic proximity Read

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across TauopathiesSemantic proximity Read

Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer’s disease and other TauopathiesSemantic proximity Read