Article

Targeting intracellular tau with a gene-encoded single-chain antibody promotes neuronal homeostasis and ameliorates tau pathology

2025-08-15

Abstract excerpt

<h4>ABSTRACT</h4> The intraneuronal aggregation of tau is a key driver of pathogenesis in tauopathies such as Alzheimer’s disease. Passive immunotherapy is a promising strategy for targeting tau, with several tau-specific antibodies having demonstrated the ability to reduce tau pathology and improve behavioural deficits in tau transgenic mouse models. Despite preclinical promise, however, conventional antibodies...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a056b245-0a57-5cd6-9fca-62bffbfa33b8
DOI: 10.1101/2025.08.13.665777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting intracellular tau with a gene-encoded single-chain antibody promotes neuronal homeostasis and ameliorates tau pathologyDOI 10.1101/2025.08.13.665777Read

Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodiesSemantic proximity Read

Targeting tauopathy with engineered tau-degrading intrabodies.Semantic proximity Read

Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disordersSemantic proximity Read

Intrabody applications in neurological disorders: progress and future prospectsSemantic proximity Read

Nanobody Therapeutics in Alzheimer’s Disease: From Molecular Mechanisms to Translational ApproachesSemantic proximity Read

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative PhenotypesSemantic proximity Read

Anti-Tau VHH Therapy Against PHF6: A Safe Approach to Slowing the Phenotype of Tau PathologySemantic proximity Read

Proteostasis as a fundamental principle of Tau immunotherapySemantic proximity Read

Inhibition of tau neuronal internalization using anti-tau single domain antibodiesSemantic proximity Read

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across TauopathiesSemantic proximity Read

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s diseaseSemantic proximity Read

Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicitySemantic proximity Read