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Modeling human pregastulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates

20 Sept 2022

Abstract excerpt

Human pluripotent stem cells provide an inexhaustible model to study human embryogenesis in vitro. Recent studies have provided diverse models to generate human blastoids by self-organization of different pluripotent stem cells or somatic reprogramming intermediates. However, whether blastoids can be generated from other cell types or whether they can recapitulate postimplantation development in vitro is unknown....

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PMID: 37155315
DOI: 10.1093/procel/pwac041

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