Article

Posttranscriptional regulation of intestinal epithelial cell repair by RNA binding protein IMP1

2018-07-12

Abstract excerpt

RNA binding proteins, such as IMP1, are emerging as essential regulators of intestinal development and cancer. IMP1 hypomorphic mice exhibit severe intestinal growth defects, yet it’s role in adult intestinal epithelium is unclear. We employed ribosome profiling to test the effect of IMP1 loss on the “translatome” in colon cancer cell lines. In parallel, we evaluated mice with intestinal epithelial-specific Imp1...

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Literature Corpus work: aa3d0c96-5521-5486-9e8e-62ed06d8e926
DOI: 10.1101/368050

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