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Article

The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis

29 Jul 2020

Abstract excerpt

Intestinal epithelial cells (IECs) exist in a metabolic state of low oxygen tension termed "physiologic hypoxia." An important factor in maintaining intestinal homeostasis is the transcription factor hypoxia-inducible factor (HIF), which is stabilized under hypoxic conditions and mediates IEC homeostatic responses to low oxygen tension. To identify HIF transcriptional targets in IEC, chromatin immunoprecipitation...

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PMID: 32726170
DOI: 10.1091/mbc.e20-05-0291

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