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Condensin-mediated restriction of retrotransposable elements facilitates brain development in <i>Drosophila melanogaster</i>

2024-01-22

Abstract excerpt

Neural stem and progenitor cell (NSPC) maintenance are essential for ensuring that organisms are born with proper brain volumes and head sizes. Microcephaly is a disorder in which babies are born with significantly smaller head sizes and cortical volumes. Mutations in subunits of the DNA organizing complexes, condensins have been identified in microcephaly patients. However the molecular mechanisms by which conden...

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Literature Corpus work
aa3a6474-43e2-55fd-98d0-cec6218a65ab
DOI
10.1101/2024.01.22.576652
Open publication

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